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Multi-label Deep Learning for Gene Function Annotation in ...

 · BP-MLL’s average precision is the second highest when confronted with the other algorithms. Nevertheless, to reach such a high average precision, BP-MLL requires 40 more training epochs than SdaMLL.

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent ...

 · MLL, involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia, has >50 known partner genes with which it is able to form in-frame fusions.Characterizing important downstream target genes of MLL and of MLL fusion proteins may provide rational therapeutic strategies for the treatment of MLL-associated leukemia.

Panhandle and reverse-panhandle PCR enable cloning of der ...

 · Depending on the exact breakpoint positions, 4–7 bp from MLL and 19–22 bp from AF were lost during the translocation. cDNA panhandle PCR identified an in-frame der(11) transcript joining MLL exon 8 to AF exon 4. A der(4) transcript fusing AF exon 3 in-frame to MLL …

Partial Tandem Duplications of the MLL Gene Are Detectable ...

The bp amplification product was sequenced and showed an exon 9/exon 3 fusion. The nucleotide sequence was exactly identical to the human bp fragment. In contrast, no MLL-duplication transcripts were detected in rat kidney, mouse spleen, and liver specimens.

Department of Computer Science, Technische Universit¨at ...

In this work, we directly build upon BP-MLL and show how a simple, single hidden layer NN may achieve a state-of-the-art performance in large-scale multi-label text clas-sification tasks. The key modifications that we suggest are (i) more efficient and more effective training by replacing BP-MLL’s pairwise ranking loss with cross entropy and

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Partial Tandem Duplications of the MLL Gene Are Detectable ...

The bp amplification product was sequenced and showed an exon 9/exon 3 fusion. The nucleotide sequence was exactly identical to the human bp fragment. In contrast, no MLL-duplication transcripts were detected in rat kidney, mouse spleen, and liver specimens.

hirise-pds.lpl.arizona.edu

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The MLL fusion gene, MLL-AF4, regulates cyclin-dependent ...

 · MLL, involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia, has >50 known partner genes with which it is able to form in-frame fusions.Characterizing important downstream target genes of MLL and of MLL fusion proteins may provide rational therapeutic strategies for the treatment of MLL-associated leukemia.

Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric ...

Direct sequencing revealed that the larger, bp frag- The MLL-AF9 breakpoint junctions are aligned with the corresponding regions of the nonrearranged cDNA MLL and AF9. ment fuses MLL exon 8 (using the numbering system of Tkachuk et al. [9]) to AF9 exon 6 (Site A, Fig. 1B) and the smaller, bp fragment fuses MLL exon 7 to the same AF9 ...

Form K

Indicate by check mark if the registrant is submitting the Form K in paper as permitted by Regulation S-T Rule 101(b) (1): ¨ Indicate by check mark if the registrant is submitting the Form K in paper as permitted by Regulation S-T Rule 101(b) (7): ¨

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MLL-ENL Causes a Reversible and myc-dependent Block of ...

The expected sizes for the amplification products were 380 bp for MLL-ENL, 400 bp for Myc, and 550 bp for the ΔMyc RNA. Some residual DNA in the RNA preparation gave rise to weak bands in the control reactions without reverse transcriptase. The standards used are a kb and a bp ladder.

Research - Münchner Leukämielabor

Moreover, MLL frequently hosts international research cooperation directly: For instance through exchange programs, our test procedures and data repositories, but also by allowing guest researchers to shadow the work of our facility and by sitting on national and international work groups.

BPMLL - LAMDA

Description: BPMLL is a package for training multi-label BP neural networks.The package includes the MATLAB code of the algorithm BP-MLL, which is designed to deal with multi-label learning. It is in particular useful when a real-world object is associated with multiple labels simultaneously.

AF4·MLL fusion protein is capable of inducing ALL in mice ...

 · Because the cloned MLL·AF4 and AF4·MLL expression cassettes have sizes of 6684 bp (MLL exons 9::AF4 exons 20) and 8738 bp (AF4 exons 1b ::MLL exons 37), respectively, the resulting proviral DNA has a length of 11 344 and 13 281 bp. This is at the limit for efficient packaging in Phoenix E cells, and thus, we expected only low titers ...

Applying multi-label techniques in emotion identification ...

The methods based on neural networks (BP-MLL and BP-MLL*) were prominent in the ranking-based measures and label-based measures, while the Ensemble method (ECC) stood out in the example-based measures. From the perspective of the adequacy of the most appropriate characteristics for the work under a multi-label approach in Sentiment Analysis, it ...

Dietary bioflavonoids induce cleavage in the MLL gene and ...

 · Quercetin- and VP induced MLL in vivo topo II cleavage sites were staggered by 4 bp (a known feature of topo II DNA cleavage sites; ref. 4) and spanned a region of 47 bp in the high affinity scaffold attachment region of the MLL BCR telomeric of exon 9 (R.S. and P.L.S., unpublished

KMT2E - Wikipedia

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized.

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Form K

Indicate by check mark if the registrant is submitting the Form K in paper as permitted by Regulation S-T Rule 101(b) (1): ¨ Indicate by check mark if the registrant is submitting the Form K in paper as permitted by Regulation S-T Rule 101(b) (7): ¨

Dietary bioflavonoids induce cleavage in the MLL gene and ...

 · Quercetin- and VP induced MLL in vivo topo II cleavage sites were staggered by 4 bp (a known feature of topo II DNA cleavage sites; ref. 4) and spanned a region of 47 bp in the high affinity scaffold attachment region of the MLL BCR telomeric of exon 9 (R.S. and P.L.S., unpublished

R3HAB - Fadil El Ghoul 🇲🇦🇳🇱 on Instagram: “I'm a fooking ...

40.8k Likes, 248 Comments - R3HAB - Fadil El Ghoul 🇲🇦🇳🇱 (@r3hab) on Instagram: “I'm a fooking ninja”

Rearrangements of the MLL gene are influenced by DNA ...

In this conformation, reflect the fact that all cell samples have the the DNA cleavage sites are aligned at the base potential to access apoptosis, a process known to of the stem, formed by a bp palindrome, with induce MLL rearrangements (Betti et al., 2001, the MLL …

2018 Week 13 MLL Top 10 Plays - YouTube

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KTM Pn√mhntijw KPVYL Pn-√m B-ip-]-{Xn-bn-se kv-{Xo-I-fp …

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The MLL recombinome of acute leukemias in 2017 | Leukemia

 · Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia ...

Rearrangements of the MLL gene are influenced by DNA ...

In this conformation, reflect the fact that all cell samples have the the DNA cleavage sites are aligned at the base potential to access apoptosis, a process known to of the stem, formed by a bp palindrome, with induce MLL rearrangements (Betti et al., 2001, the MLL …

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